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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

Ree, R., Varland, S., & Arnesen, T

Oxidative stress due to these free radicals containing unpaired electrons can damage cells and the DNA leading to several diseases and even cancers, dementia, Alzheimers disease, Parkinsons disease and coronary heart disease

Although pharmacotherapy remains central to SLE management, current treatment strategies have limitations, such as inadequate response or side effects in some patients