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The present trial was designed to identify the presence of genetic variance in the glutathione allele as risk factor for SOS

Additionally, autophagy plays an important role in CRPC [43, 44], and -ketoglutarate generated by glutamine metabolism functions via the TCA cycle and synthesizes biological macromolecules and acts as a cofactor for the histone demethylases JmjC-KDMs and members of the DNA demethylase TET family, participating in promoting histone and DNA demethylation processes and regulating gene expression [45]

This condition is characterized by patchy areas of inflammation, often referred to as "skip lesions," which can penetrate deep into the layers of the intestinal wall, causing fistulas, abscesses, and strictures

We expect that this manuscript can provide a new perspective for clinical treatment of related diseases