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While the TECOS trial reported neutral cardiovascular effects for sitagliptin, other agents like saxagliptin are associated with increased HF hospitalization risk (78)

Methylcobalamin facilitates the conversion of homocysteine to methionine, reducing neurotoxic homocysteine levels by 30-40% (NIH 2025 longitudinal study, n=1,200 elderly, aged 65-85)