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FIGURE 8 Nine different substances were declared as PCT medicines in the samples and, in order of occurrence frequency, they were hCG (n = 16), clomiphene (n = 14), tamoxifen (n = 7), exemestane (n = 7), anastrozole (n = 7), cabergoline (n = 6), mesterolone (n = 4), and letrozole (n = 2)

The combined supplementation of these vitamins has been shown to provide enhanced neuroprotective effects compared to individual vitamin supplementation [12], suggesting that a comprehensive approach to B vitamin therapy could be more effective in preventing and treating PNs of different etiologies, such as DPN and idiopathic peripheral neuropathy

The 12-week Phase IIb trial in 300 obese adults, with 1mg daily dosing, produced an average weight loss of 2.6 kg compared with 0.8 kg in the placebo group

Both study protocols were approved by the Medical Ethics Review Committee of the Radboud University Medical Centre and the Local Ethical Committee of Rijnstate Hospital Arnhem, and were conducted in concordance with the principles of the Declaration of Helsinki