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90 Histone demethylase KDM3B is another potential epigenetic regulator of ferroptosis, as it upregulates the expression of SLC7A11, indicating that ferroptosis is influenced by epigenetic mechanisms

For example, Bifidobacterium promote the proliferation of beneficial commensals and inhibit the growth of pathogenic bacteria, thereby improving intestinal barrier function and nutrient absorption efficiency (Li et al., 2025)

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Interestingly, FTC patients with partially or hypermethylated SLC5A8 exhibited higher recurrence rates during a 5-year follow-up compared to those with hypomethylated SLC5A8 , suggesting that methylation analysis of this gene could serve as a valuable prognostic tool for predicting clinical outcomes in FTC patients [210]