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Vitamin B12 is essential in nucleic acid and myelin protein synthesis

Trials that specifically enroll healthy adults with normal B12 and ask whether supplementation suppresses hunger or causes weight loss are few and generally small or uncontrolled

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175-178 Nevertheless, niacin has demonstrated antithrombotic effects, including inhibiting a coagulation cascade enzyme called factor VII, reducing fibrinogen levels, decreasing expression of tissue factor, suppressing plasminogen activator inhibitor-1 (an enzyme that inhibits fibrinolysis), lowering blood viscosity, and decreasing platelet aggregation