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TDP-43 pathology was originally defined with the accumulation of proteins that include phosphorylated TDP-43 (pTDP-43) in the cytoplasm of neurons that undergo degeneration 10 , and this pathology was broadly observed in a wide spectrum of ALS cases 44

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In terms of new research avenues in the NAD + field, it is also emerging that apart from its effects on the mitochondria, NAD + plays a multitude of roles in regulating both metabolic and non-metabolic processes

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