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In women over 45 years old, menopause is detected based on the clinical picture: variability, lengthening, and cessation of the menstrual cycle can be accurately presumed to indicate perimenopause or postmenopause

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Expert Opinion on Investigational Drugs 17, (1) (Jan): 1-12

335 Quercetin, which targets the Bcl-2 family member hypoxia-inducible factor-1 (HIF-1) and the antiapoptotic PI3K/AKT and p21 signaling pathways, has demonstrated synergistic effects (Table 1)