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The oocytes are encompassed in cumulus cells (CC), which are responsible for supporting all throughout the gamete development

While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019

Sustained inflammation and oxidative stress can promote the activation and proliferation of HSCs, exacerbating the deposition of extracellular matrix and leading to the formation of fibrosis [224]

The exact mechanism of ICI-related cardiotoxicity remains unclear, however proposed mechanisms include shared antigen between tumor and myocardium, T-cell receptor targeting homologous muscle antigen or certain T-cell receptors targeting dissimilar antigens (209)