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10.1016/j.biopha.2016.04.020 63 GhorbaniA.AmiriM

This has become evident mostly in recent years with the advent of single-cell RNA sequencing techniques, which have helped to unravel the vast heterogeneity and plasticity of this cell type ( Another important conceptual shift in the field of fibroblast research is the recognition that these cells can be drivers of disease, rather than mere responders to the inflammatory or pathogenic microenvironment