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Kendall, Kristina L., et al

Prophylactic immunization with this band in a mouse model of breast cancer extended their survival time, inhibited breast tumor growth, and reduced metastasis by increasing levels of tumor necrosis factor-alpha (TNF-), interleukin-2 ( IL-2), IL-4, and interferon-gamma (IFN-) [41, 53]

Conversely, support for the Marker Hypothesis suggests that disease associations may result from the loss of native gut commensals rather than a substantial rise in oral bacteria numbers, granting these oral taxa pathogenic potential in the gut environment 33

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