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[DOI] [PubMed] [Google Scholar] 96.Chae Y.K., Ranganath K., Hammerman P.S., Vaklavas C., Mohindra N., Kalyan A., Matsangou M., Costa R., Carneiro B., Villaflor V.M., et al

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Although the acute intravenous administration of amlodipine decreases arterial blood pressure and increases heart rate in hemodynamic studies of patients with chronic stable angina, chronic oral administration of amlodipine in clinical trials did not lead to clinically significant changes in heart rate or blood pressures in normotensive patients with angina

These approaches encompass top-down and bottom-up strategies, green or biomass derived synthesis routes, as well as downstream purification and scale-up processes