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[Abstract]2020 Aug;152:129-138

Complete randomization is not feasible in observational studies investigating the effects of harmful substances, thereby limiting the analysis to the data available (Carlson and Morrison 2009)

This 28day guideline comes from the USP Compounding Standards, which sets standards for sterile compounding and states that an opened multidose vial with antimicrobial preservative should be discarded within 28 days unless the manufacturer specifies otherwise

Both are diagnosed by applying the 2017 diagnostic criteria, which also excludes other less common conditions presenting with joint hypermobility such as other forms of EDS and heritable connective tissue disorders