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Daraxonrasib , made by Revolution Medicines, has changed that: it first binds a scaffolding protein (called Cyclophilin A) and then RAS, which locks it into an inactive state: This mechanism means that Daraxonrasib inhibits many of the major RAS mutations: Pancreatic cancer is addicted to this continuous RAS activity so if its inhibited, tumours should shrink

The activation of these pathways can cause apoptosis of proximal tubular cells and paracrine effects that incite the development of interstitial inflammation and fibrosis, ultimately leading to irreversible kidney injury

Through these interactions, a self-reinforcing positive feedback loop emerges between metabolic dysregulation and inflammation