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Astrocytic autophagy plasticityboosting degradation of pathological proteins Neurons exposed to -amyloid oligomers fail to cope with this proteotoxic stress, leading to a reduction in the expression of autophagy-related genes (MAP1LC3B/LC3B and SQSTM1/p62, two key autophagy-related genes) alongside a decrease in microtubule-associated protein 2 (MAP2)

The oncogenic properties of copper involve multiple interconnected mechanisms: (1) activation of LOX-mediated collagen deposition, driving OSF progression (36)

Table 3 Actionable research priorities and proposed interventions for advancing Parkinsons disease treatment

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