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The observed percent changes in TEMPO-CNFs concentrations in test solutions prepared with ultra-pure water, very soft synthetic water, and blended water were less than 20%, which was used as a guide for dispersion stability in the OECD guidance for nanomaterials and is considered acceptable (OECD 2021)

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If pralidoxime is administered before adequate atropinization , it may temporarily worsen life-threatening muscarinic effects, including: Bronchoconstriction Increased respiratory secretions , which can lead to airway obstruction Therefore, clinical guidelines recommend administering atropine before pralidoxime , and this sequence is reflected in autoinjector design (Aman et al., 2021