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AF is most commonly associated with advanced age, hypertension, diabetes mellitus, thyroid dysfunction, obesity, alcohol use, physical inactivity, and underlying ischemic heart diseases

Guo et al., 2016), the European Food Safety Authority estimated that the change of the urinary excretion rate of riboflavin corresponding to the point of tissue saturation could be achieved by a riboflavin intake of around 1.3mg/d (EFSA, 2017)