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linker types that have been used to conjugate a cytotoxin or a drug to an antibody include, but are not limited to, hydrazones, thioethers, esters, disulfides and peptide-containing linkers

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Nevertheless, based on the promising pre-clinical and early-phase clinical trial findings in the colorectal cancer setting [12, 13, 32, 151], a Chinese phase III trial aiming to evaluate the effectiveness of combing high dose IV VitC (1.5 g/kg) with FOLOX +/ bevacizumab versus treatment with FOLFOX +/ bevacizumab alone as first-line therapy in patients with recurrent or advanced colorectal cancer is currently ongoing (ClinicalTrials.gov Identifier: NCT02969681, Table 3, recruiting status unclear)

[DOI] [PubMed] [PMC] Zhang C, Yang M