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Resveratrol inhibits glioblastoma cells and chemoresistance progression through blockade P-glycoprotein and targeting AKT/PTEN signaling pathway

Research question formulation The research question (RQ) of this study was formulated using the PICO (Population, Intervention, Comparison, Outcomes) framework

Inhibition of cystathioninelyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS

These limitations result in rapid degradation within the bloodstream, necessitating higher doses and prolonged treatment regimens (Michala and Pritsa, 2022)