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HIF can directly bind the PIK3CA promoter to enhance its transcription, thereby stabilizing and amplifying the drug-resistant phenotype

therefore, they are unable to effectively eliminate excess ROS, resulting in ROS accumulation and OS (26)

The exercise sessions were conducted for a duration ranging from 60 to 90 minutes, three times weekly, maintaining an intensity of 50 to 70% of the target heart rate, while participants ingested 100 mL of pomegranate juice prior to each exercise session

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