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For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption

DOI: 10.1021/ar00009a003 [4] MASAYASU INOUE

This condition arises when the skins pigment-producing cellsmelanocytesbegin to produce excess melanin, which causes uneven skin tone

1156/11/21, Gliwice, Poland), DPPH (#STBB0828V, SigmaAldrich, Taufkirchen, Germany), MTT (#MKCR0748, Sigma-Aldrich, Taufkirchen, Germany), catechin-amino2-(hydroxymethyl)-1,3-propanediol (Trizma-Base) (Lot # BCBF0735V, Sigma-Aldrich, Taufkirchen, Germany), Triton X-100 (#STBH6272, Sigma-Aldrich, Taufkirchen, Germany), phosphate-buffered saline (PBS) (#SLCL7026, Sigma-Aldrich, Taufkirchen, Germany), dimethyl sulfoxide (DMSO) (#BCCJ0028, Sigma-Aldrich, Taufkirchen, Germany), ABTS (#SLCH6886, Sigma-Aldrich, Taufkirchen, Germany)