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The downstream signals of AT 1 receptor activation involved in DPN development remain to be investigated in future studies, although stimulation of AT 1 receptors is known to cause oxidative stress 44 which could be involved in the pathogenesis of DPN 45

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Int J PharmTech Res 8:3140 Islan GA, Das S, Cacicedo ML et al (2019) Silybin-conjugated gold nanoparticles for antimicrobial chemotherapy against Gram-negative bacteria