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Mitochondrial damage not only compromises their own function but can also negatively impact other cellular components, including organelles, proteins, and membranes

doi: 10.1016/j.molcel.2017.12.021 37 ReniereM

Inhibiting LPCAT3 can make cancer cells less sensitive to ferroptosis, and experimenters exposed kidney cancer cell lines treated with LPCAT3 inhibitors to certain concentrations of ferroptosis inducers and found that the treated cells were insensitive to ferroptosis, while the levels of arachidonic acid phospholipids decreased significantly, indicating that inhibiting LPCAT3 decreased the synthesis of specific lipids that trigger ferroptosis, and the cells were much less likely to undergo ferroptosis, confirming the important role of LPCAT3 in ferroptosis (28)

FEMS Microbiol Rev 29 , 10411050, (2005)