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Mol Cell Endocrinol 464, 65-74 (2018)

A simplified snapshot as of mid-2026: FDA-approved (legal by prescription): semaglutide and tirzepatide (GLP-1 medications for weight and metabolic health) and tesamorelin

PDI accelerates disulfide interchange in kinetically trapped intermediates, shuffling these disulfides until the most stable protein configuration is achieved

GPR3 and GPR12 have roles in female reproduction through ovarian aging, where both receptors maintain meiotic arrest of oocytes and premature ovarian aging (Hinckley et al