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While the Lipinskis Rule of Five remains a cornerstone for evaluating oral drug-likeness (molecular weight 5) and failed the Veber, Egan, and Muegge rules owing to its high TPSA and hydrogen-bonding capacity

Besides, the most serious barrier to the clinical use of anti-cancer AMPs remains the enzymatic degradation and inactivation of these cytotoxic peptides through interactions with negatively charged serum proteins

Chemoprevention of N-nitroso-N-methylurea-induced mammary cancers by pretreatment with 17 beta-estradiol and progesterone

Saponins are surface active compounds having five- or four-ring triterpenes with cardioprotective potential and can be involved in calcium homeostasis, regulation of energy metabolism, inflammation stopping, and oxidative stress