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Specifically, Tank-binding kinase 1 (TBK1) can phosphorylate NDP52 and OPTN to enhance their activity (Richter et al., 2016), which is activated by the PINK1-parkin pathway after mitochondrial damage, which is also a feedforward mechanism ( Autophagy receptors on OMM in ototoxicity As mentioned above, BNIP3L/NIX, BNIP3, and FUNDC1, several specific receptors localized on OMM, also participate in the induction of mitophagy via direct interaction with LC3 ( BNIP3L/NIX was initially reported to restore mitochondrial sequestration from red blood cells during maturation (Sandoval et al., 2008)

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Tell your doctor if you are pregnant or breastfeeding during Eliquis treatment

Nevertheless, those papers taking into account shorter time points show that a good temporal concordance exist between MIE (4 h), KE2 (6 h) and KE3 (1224 h) (Ding, 2001