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Conclusions There appears to be no significant marginal benefit in terms of all-cause mortality, heart failure, unstable angina, or myocardial reinfarction in the setting of acute MI for oral L-carnitine maintenance doses of greater or less than 3 g per day

K.et al (2022b)

While most people can benefit from this pairing, certain groups will see the most significant impact

For these reasons, leucovorin has been used to treat epileptic patients having mutations in the folate receptor alpha gene, FOLR1 (Mafi et al ., 2020), as well as in the context of cancer chemotherapy to decrease the toxic effects of methotrexate, an inhibitor of the DHFR