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In conclusion, the strategic targeting of critical enzymes within the glycolytic pathway, lactate transporters, or enzymes responsible for lactylation, has garnered substantial foundational research in the realm of antitumor therapy

171 In a placebo-controlled trial in 75 healthy male adolescents, 28 days of supplementing with 250 mg or 500 mg of citicoline daily led to increased attention and reaction speed and decreased impulsivity

Animal studies have extended to 180 days in rodents without detecting organ toxicity, but no human trials have tracked outcomes beyond three months

PubMed , European Journal of Pharmacology , vol