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The last study published in 2024 by Zmitek et al

Mod Rheumatol

In addition to DNAm, cigarette smoking is linked to the activation of enzymes that regulate other types of epigenetic modifications (i.e., post-translational modifications of histones via methylation, acetylation, phosphorylation, ubiquitination, and regulation of non-coding RNA sequences) to mediate the expression of multiple inflammatory genes, thereby participating in the onset development of autoinflammatory diseases (135)

Introduction Adverse childhood experiences (ACEs) such as abuse, neglect, loss, and other traumas, represent significant risk factors for subsequent mental illness and suicide