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Simultaneously, in the extracellular pathway, drugs penetrate the nasal epithelium and enter the lamina propria, then move along the perineural spaces surrounding olfactory and trigeminal axons, allowing both small and large molecules to reach the CNS

Under normoxic conditions, the proline residue of HIF1 is hydroxylated

In particular, the relevance of the ATB 0,+ -mediated carnitine transport, in patients with PCD, may be explained considering that this protein is highly expressed in the intestine (Figure 2)

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