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Unlike fat-soluble vitamins that require fat for absorption and are stored in the liver, water-soluble vitamins like B12 are processed more quickly by the body and are not stored for long-term use

However, most drugs may be cleared and swallowed by mucociliary movement, limiting the quantity of drugs entering the lymphatic system [45]

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For example, the clinical relevance of a HOTAIR-IGFBP-2 pathway in renal cell carcinoma is demonstrated by Kaplan-Meier analyses showing decreased cancer-specific survival associated with high expression of both HOTAIR and IGFBP-2, with lowest survival when both are high