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Description

Shoemaker RC, Hudnell HK

Wangpaichitr et al

Interestingly, Nrf2 expression is significantly downregulated in peritoneal tissue-resident macrophages isolated from Immune-responsive gene 1 ( Irg1 ) shRNA-injected tumor-bearing mouse (79)

In this way, ROS are the main mediators of the toxic and inflammatory destruction of hepatocytes, by inducing mitochondrial dysfunction via increasing intracellular oxidant stress, ultimately leading to cell necrosis [20]