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Patients with MDD exhibit KP dysregulation, often marked by an overproduction of quinolinic acid, an N-Methyl-D-aspartic acid receptor (NMDAR) agonist that drives excitotoxicity, alongside reduced production of kynurenic acid, an NMDAR antagonist that protects from excitotoxicity and has anti-inflammatory effects

The heavy chains of the nAbs reach the RBD and interact with the cradle-like surface or the flexible ridge region

doi: 10.3390/biology8030057 61 LudwigRGRochaALMoriMA

Peeling could be a sign of dehydration dry lips, but it can also be triggered by lip licking, spicy or citrusy foods, and allergic reactions to lip products