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doi: 10.1007/s00394-018-1876-x 100 KhorsandiHNikpayamOYousefiRParandooshMHosseinzadehNSaidpourAet al

discoideum induce a rapid burst of reactive oxygen species (ROS) production

Also, in vitro studies indicate that the responsiveness of pro-B cells to IL-7 is compromised in aged individuals [355], and IL-7 release from stromal cells in the bone marrow also declines with age [356], leading to reduced pro B-cell proliferation