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(68) highlighted in their review that pH-sensitive nanoparticles- commonly composed of materials such as alginate and chitosan- can modulate their size, solubility, and drug release rate in response to pH-dependent physicochemical changes

in fact, it can also favor cancer development due to its potential negative impact on anticancer immunity (366)

Compared with patients with normal nucleus pulposus, patients with lumbar disc herniation presented higher haemoglobin concentrations in the disc nucleus pulposus, a higher quantity of dark iron particles following staining, and elevated expression levels of HO-1 (177)