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While tests such as CVLT, BNT, and UPSIT offer valuable diagnostic insight, particularly in early or prodromal stages, their limited dynamic range and susceptibility to ceiling or floor effects constrain their utility as response biomarkers

For example, Bentamapimod has completed a phase 2 trial of endometriosis, and Tanzisertib has been investigated in multiple clinical trials, including for idiopathic pulmonary fibrosis

On the other hand, despite the observed GSH depletion and induction of GCLC protein expression in APAP-CYS treated cells, there was observed no significant ROS production after APAP-CYS treatment

While our study confirms that LicoA alleviates cisplatin-induced nephrotoxicity by activating the Nrf2/GPX4 axis and inhibiting ferroptosis, there are several limitations that should be addressed in future investigations