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J Pharmacol Exp Ther (2011) 339:50918.10.1124/jpet.111.185694 135 KawasLHMcCoyATYamamotoBJWrightJWHardingJW

The First Enzymatic Step in Mercapturic Acid Formation, The Journal of Biological Chemistry , Vol

According to Li et al., mitochondrial oxidative damage was brought on by erastin, an established inducer of ferroptosis

In vivo experiments indicated that AGNHP inhibits ROS, LPO, and Fe 2+ accumulations in MCAO and ICH rats ( in vitro experiments shown that AGNHP mitigated ferroptosis damage caused by erastin in PC12 cells, enhanced cell survival, decreased LPO and Fe 2+ concentrations, and boosted mRNA expressions of PPAR, AKT, and GPX4 ( Di-Huang-Yin-Zi (DHYZ) is a traditional herbal medicine employed for the prevention and treatment of neurological disorders since the Song Dynasty