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Description

Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin

In contrast to the X-ray structure of GIRK2 apo (Whorton and MacKinnon, 2011), where the CTD is engaged with the TMD in the apo state, cryo-EM structures showed the CTD distancing from the TMD in the apo state (the extended TM-CTD) (Figure 3)