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Cancer Res (1999) 59(17):438391

Abstract Intervertebral disc degeneration (IVDD) is the leading cause of chronic low back pain (LBP), driven by a pathological microenvironment marked by acidic pH, increased reactive oxygen species (ROS), and elevated matrix metalloproteinase (MMP) activity, which hinder tissue regeneration

There is evidence that viral infections (hepatitis C, HIV and influenza) are associated with an increased production of ROS and that could be involved in the pathogenesis [33,34]

Increased preference for gentle, non-stripping formulations suitable for sensitive skin types, which bubble foam cleansers often provide