glutathione synthetase structure synthesis. GSH synthesis relies on the enzymatic activities Glutathione (GSH)

C1-31 (4YQU) and C4-10 (4YQV)

The expression of mitochondrial methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), which is necessary for purine synthesis, depends on ATF4

J Neurochem 82:716719 Hirrlinger J, Moeller H, Kirchhoff F, Dringen R (2005) Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study

Beyond Barriers is confident the results will be more robust when delivered intranasally. Using a repurposed drug lets the company pursue the 505(b)(2) FDA approval pathway, which Kole says, has a three-fold better chance of success of approval than the traditional 505(b)(1) route and is less expensive and time-intensive. Administration doses and schedules are to be determined, but early research suggests the administration window may be as long as 72 hours after injury