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Nuclear factor erythroid 2-related factor 2 plays a fundamental role in the response to oxidative stress and xenobiotic metabolism and detoxification, and the Nrf2 signaling pathway is intimately associated with development of atherosclerosis

Another effect of aging is capillary loss, accompanied by a decline in SIRT1 activity and NAD + levels

TAMS) have diverse roles, with M1 TAMs promoting anti-tumor activity by inducing antibody-dependent cell-mediated cytotoxicity and facilitating CD8+ directed cytolytic killing by presenting tumor-specific antigens (88, 89)

Ventura E, Ducci G, Benot Dominguez R, Ruggiero V, Belfiore A, Sacco E, Vanoni M, Iozzo RV, Giordano A, Morrione A