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10.1111/bjh.17091 10

The main barriers to the widespread use of EDs include poor palatability, high out-of-pocket cost, and lack of provider awareness

doi: 10.1046/j.1365-2265.2001.01286.x 45 KinemanR

It is also essential for folate and related one-carbon metabolism, where FAD is required as a cofactor for methylenetetrahydrofolate reductase (MTHFR), a key folate-metabolizing enzyme