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Perhaps most importantly for weight management, choline is involved in the transport of lipids (fats) from the liver, which not only supports overall liver health and function but also helps prevent excessive fat accumulation in this vital organ

10.1016/j.jemermed.2021.07.034 191

Synthetic hormones, specifically progestins, by an oral route led to the creation of metabolites in the liver which caused an increase in the incidence of breast and uterine cancers