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The target of the injections for chronic migraine is just below the skin and above the muscle layer

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Research published in the Annals of the New York Academy of Sciences by Goldstein et al

Handling and Storage Recommendations Store unopened vials at 28 C, with 20 C recommended for long-term storage Protect from light and moisture After reconstitution, store solutions at 28 C and use within laboratory-defined timeframes Avoid repeated freeze-thaw cycles Follow standard laboratory safety, labeling, and handling procedures All handling is performed within laboratory research environments