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20: 566577 (2020) Peres LAB, Cunha Jnior AD da

The rationale for combining these two peptides is mechanistic complementarity

Indeed, K3 also forms hydrogen bonds with H95 and Q99 in common with AMG510, albeit with different orientations of H95

One strategy involves constructing chimeric agents that combine the structural motif of two anticancer agents, such as photodynamic cyanine dyes and cytostatic drugs