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OPNAs exert their toxic effects primarily by irreversibly inhibiting acetylcholinesterase (AChE), accumulating acetylcholine at synapses, and causing cholinergic crisis

After its synthesis, almost 90 % is retained into the cytoplasm [2, 3]

1.1.3 MIND diet Morris et colleagues

Emerging gene-editing technologies, particularly CRISPR/Cas9, now allow for the precise introduction of human disease-associated alleles or even the replacement of zebrafish genes with their human counterparts, creating humanized models that promise far greater fidelity in mimicking human pathology and pharmacological response (Schellens et al., 2022)