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The theory postulates that external stressors stimulate an immune response in the gut, which triggers and seeds pathology from the enteric system to the brain via the vagal nerve 33

However, the role of meldonium in the regulation of nitric oxide (NO) production can also be considered as the way of meldonium antioxidative action

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Because both versions can perform biological functions in various settings, they often refer to the pair ALA/DHLA without indicating any distinctions [8,58]