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In Study JMCH, incidences of Grade 3 to 4 neutropenia (38% versus 23%), thrombocytopenia (9% versus 5%), febrile neutropenia (9% versus 0.6%), and neutropenic infection (6% versus 0) were higher in patients who received pemetrexed plus cisplatin without vitamin supplementation as compared to patients who were fully supplemented with folic acid and vitamin B12 prior to and throughout pemetrexed plus cisplatin treatment

On the other hand, CD38 ligation by daratumumab leads to aggregation of protein:antibody complexes, formation of distinct polar aggregates, and subsequent release of microvesicles (MVs)

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In a randomized, double-blinded, placebo-controlled trial, compared with placebo, liraglutide reduced IL-6 with concomitant numerical reductions in other proinflammatory cytokines