glutathione in ovarian cancer a double-edged sword

glutathione in ovarian cancer a double-edged sword Targeting ferroptosis cancer: Novel strategies to overcome chemotherapy resistance Frontiers | Ferroptosis: a dual-edged

Name: glutathione in ovarian cancer a double-edged sword Targeting ferroptosis cancer: Novel strategies to overcome chemotherapy resistance Frontiers | Ferroptosis: a dual-edged
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Frontiers Ferroptosis: a dual edged sword in tumour growth Metabolic reprogramming of three major nutrients in platinum resistant ovarian cancer PMC The crosstalk between glutathione metabolism and non coding RNAs in cancer progression and treatment resistance ScienceDirect Redox Regulated Iron Metabolism and Ferroptosis in Ovarian Cancer: Molecular Insights and Therapeutic Opportunities

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doi:10.1016/j.arr.2022.101766

Compared to healthy controls, SCD patients have significantly lower erythrocyte GSH and cysteine concentrations 12 and a faster rate of GSH synthesis, suggesting that the endogenous cysteine supply is insufficient to meet all anabolic demands

Of the patients with severe elevation in liver enzymes, n=19 (95%) occurred while critically ill in the ICU

Firstly, we verified across a panel of normal and cancer cell lines with differing p53 status (Supplementary Table 1) that treatment with a lethal dose of APR-246 resulted in higher intracellular ROS (Fig