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Exploring the Side Effects: What You Need to Be Aware Of While glutathione is generally regarded as safe when taken at adequate levels, there are certain potential adverse effects to be aware of, particularly when utilising high doses or receiving intravenous (IV) glutathione injections

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Sterol regulatory element-binding protein 2 (SREBP2) acts as the master transcriptional regulator (129): cholesterol depletion triggers the translocation of SCAP-SREBP2 complex to the Golgi, where proteolytic cleavage releases nuclear SREBP2 (nSREBP2) to upregulate cholesterol synthesis genes (e.g., HMGCR, SQLE), cholesterol sufficiency retains the complex in the ER via SCAP-INSIG binding (130)